There are different opinions with international levels about Covid-19.1 In the beginning, Covid ‘19 was spread through community contamination, later it was suspected airborne, waterborne, and community contaminations. In the early period, Covid-19 was suspected only viral disease recently it is found that it causing mutations and point mutations.2 Protein genes mutations and point mutations are irregular and unstable.3 Researchers, Scientists, and Clinicians are trying for plasma therapy and immune cell therapy.4 It is a hypothetical theory that might be soon gene therapy will be followed for the affected genes causing mutations and point mutations. COVID-19 patients have a favorable prognosis, but some rapidly progress to severe and critical cases with respiratory distress syndrome, coagulation dysfunction, multiple organ failure, etc.5 Therefore, early identification of severity is very important to the clinical diagnosis and treatment for COVID-19. Mostly used clinical laboratory coagulation profiles and other enzymes related to D- Dimer, Ferritin, Lactate Dehydrogenase, C Reactive Protein, Prothrombin Time, Activate Partial Prothrombin Time and fibrinogen could sensitively reflect the clotting state and enzymatic activity of the body.6
This study aims to investigate the elevation and significance of D- Dimer, Ferritin, Lactate Dehydrogenase, C – reactive protein, prothrombin time and activated partial thromboplastin time are found the indicators of suspected covid – 19 patients.
Materials and Methods
A total number of 300 suspected patients and 200 healthy controls were enrolled for the study and compared their data for the elevation and significance of D- Dimer – Ferritin – Lactate Dehydrogenase - C - protein – prothrombin time and activated partial prothrombin time are found the indicators of suspected covid – 19 patients. 7, 8
This study was carried at Biochemistry Laboratory, Ayaan Hospital & Research Centre (A teaching hospital to Ayaan Institute of Medical Sciences, RR District, Telangana State, India).
The parameters were done on Cobas C 311, Mini Vidas, and Coagulometer.
Comparison of D- Dimer, Ferritin, Lactate Dehydrogenase, C Reactive Protein, Prothrombin Time, Activated Partial Thromboplastin Time in COVID-19 patients and health controls.
The results have shown that there are elevation and significance indicators of D- Dimer, Ferritin, Lactate Dehydrogenase, C – Reactive Protein, Prothrombin Time, Activated Partial Thromboplastin Time in COVID-19 Patients which were compared to Healthy Controls for their normal limits.9
Although the above investigations are associated with severe disease of COVID 19. The values are at high risk of disease COVID 19. The COVID 19 pandemic disrupted medical science and management. These days researchers are intensely looking for suitable vaccines and clinicians are facing new symptoms of the disease and are using new treatments to improve the outcome of the disease.10