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Volume : 2, Issue : 3, Year : 2015
Article Page : 140-142
Background: Type 2 Diabetes Mellitus (T2DM) is a progressive disease characterized by both insulin resistance and β-cell dysfunction. Several studies have revealed the inverse relationship between vitamin D deficiency and T2DM. Vitamin D deficiency is thought to influence insulin resistance and the pathogenesis of T2DM by affecting either insulin sensitivity or β-cell function or both. It has been shown that vitamin D replenishment improves insulin sensitivity in patients with T2DM and also decreases the progression of diabetic neuropathy. The presence of vitamin D receptors (VDR) and vitamin D binding proteins (DBP) in pancreatic tissue and the relationship between certain allelic variation in the VDR and DBP genes with glucose tolerance and insulin secretion have further supported this hypothesis.
How to cite : Lakshmi G, Jothimalar, Silambanan S, Vitamin D Status in Type 2 Diabetes Mellitus. Int J Clin Biochem Res 2015;2(3):140-142
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