International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...


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Original Article


Article page

392-396


Authors Details

Mayur Rai, Tirthal Rai, Srinidhi Rai, Janice D’Sa, Parinita K


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Serum osteocalcin: A potential biomarker for primary osteoporosis


Original Article

Author Details : Mayur Rai, Tirthal Rai, Srinidhi Rai, Janice D’Sa, Parinita K

Volume : 5, Issue : 3, Year : 2018

Article Page : 392-396

https://doi.org/10.18231/2394-6377.2018.0082



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Abstract

Osteoporosis is a silent killer usually asymptomatic and noticed only after a fracture. Women irrespective of their origin and social strata show an accelerated phase of bone loss, for about 10 yrs after the cessation of ovarian function due to hormonal imbalance. Until now for the diagnosis of osteoporosis Bone mineral density (BMD) and DEXA was used, which is costly hence bone turns over markers have come to vogue in suggesting the risk of osteoporotic fractures.
Objectives of the Study: To assess the potentiality of serum osteocalcin as a diagnostic tool for osteoporosis in post menopausal women and thus overcome the risk of fractures.
Materials and Methods: This study was conducted on 50 apparently healthy pre menopausal women and 50 postmenopausal women with immediate fractures sustained as a result of trivial trauma.
Results: The mean serum osteocalcin level was (2.63 ± 1.76) in the post menopausal women with fractures as compared to the pre menopausal women (5.55 ± 2.92) which was statistically significant.
(p value <0> Conclusion: Osteocalcin is a highly sensitive bone formation marker and can be used as a diagnostic or screening tool in post menopausal women for Osteoporosis. The decreased serum osteocalcin levels after menopause could hence predict and prevent the risk of fractures.

Keywords: Osteocalcin, Pre-menopausal women, Postmenopausal women with fractures, Calcium, Phosphorous, Alkaline phosphatase, Total protein, Albumin and osteoporosis.


How to cite : Rai M, Rai T, Rai S, D’sa J, Parinita K, Serum osteocalcin: A potential biomarker for primary osteoporosis. Int J Clin Biochem Res 2018;5(3):392-396

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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