International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...


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Original Article


Article page

361-364


Authors Details

Sanjeev Kumar Singh, Dharmveer Sharma, Nivedita Singh, Raj Kumar, Pavan Gautam5


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Status of high sensitive C- reactive protein (hs-CRP) in NAFLD obese type-2 diabetic subjects


Original Article

Author Details : Sanjeev Kumar Singh, Dharmveer Sharma, Nivedita Singh, Raj Kumar, Pavan Gautam5

Volume : 5, Issue : 3, Year : 2018

Article Page : 361-364

https://doi.org/10.18231/2394-6377.2018.0075



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Abstract

Introduction: Non alcoholic fatty liver disease (NAFLD) is a disease occurring in patients without any significant alcohol consumption. It includes a broad spectrum and advanced forms of liver diseases, from simple steatosis to nonalcoholic steatohepatitis, fibrosis, and cirrhosis and is associated with diabetes mellitus, insulin resistance, obesity, dyslipidemia and metabolic syndrome. The aim of this study is to evaluate the metabolic significance of NAFLD in obese and type-2 diabetic subjects compare to healthy group of individuals and those independent factors associated with NAFLD.
Materials and Methods: Our study was conducted in Govt. Medial College, Banda (UP) as well as G. R. Medical College, Gwalior (MP). A total of 200 subjects were involved in our study, diagnosis being based on ultrasonography. Out of these, 100 were obese with type-2 diabetic patients and 100 were healthy subjects. They were evaluated by measurement of BMI and several biochemical blood parameters such as fasting blood glucose, lipid profile, liver function tests (ALT, ALP and GGT) and hs-CRP level.
Results: An increase in the BMI and levels of FBS, total cholesterol, triglycerides, LDL, VLDL, GGT, ALT, ALP and hs-CRP level and a decrease in HDL was observed in NAFLD group of individuals. The values of these biochemical markers were found higher in NAFLD patients and the variations were found to be statically significant. BMI and triglycerides were positively correlated with fatty liver.
Conclusion: Obesity, hyperglycemia, dyslipidemia and increased liver enzymes and hs-CRP level are seen more commonly in non alcoholic fatty liver in type-2 diabetic obese patients.

Keywords: NAFLD, BMI, High sensitive C-reactive protein.


How to cite : Singh S K, Sharma D, Singh N, Kumar R, Gautam5 P, Status of high sensitive C- reactive protein (hs-CRP) in NAFLD obese type-2 diabetic subjects. Int J Clin Biochem Res 2018;5(3):361-364

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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