International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...
Author Details :
Volume : 5, Issue : 2, Year : 2018
Article Page : 348-352
Introduction: Pregnancy induced hypertension is considered as the major cause of maternal and perinatal mortality. Even though occurrence of PIH is due to abnormal placentation, endothelial dysfunction (ED) plays a pivotal role in the genesis of the multisystem disorder that develops in pre eclampsia and eclampsia. Excessive inflammation might lead to ED. So, a study has been designed to analyse some inflammatory markers (TNF-?, HsCRP, IL-6) and their association with endothelial dysfunction (NO) in PIH women.
Materials and Methods:Study group consisted of Normotensive pregnant women (N) preclamptic women (PE) and eclamptic women (E) with 100 subjects in each group in the 3rd trimester of pregnancy. They were investigated for TNF-?, IL-6, HsCRP & NO. Statistical analysis was done using ANOVA
Results:When compared to controls TNF-?, IL-6, HsCRP levels were found to be significantly high & NO levels were significantly low in PE, E group. Eclamptic women showed a significantly high level of TNF-?, and low levels of NO when compared to PE group.
Conclusion:Early careful monitoring of TNF-? along with NO might be helpful to predict the origination and advancement of the disease. It may help in emerging approaches for diagnosis and prevention of maternal and fetal complications.
Keywords: PIH- Pregnancy induced hypertension, TNF-? – Tumor necrosis factor-alpha, IL-6 – Interleukin-6, HsCRP-High sensitive C-reactive protein, NO- Nitric oxide
How to cite : Visalasree J, Abraham P, Association of inflammation with endothelial dysfunction in pregnancy induced hypertensive women. Int J Clin Biochem Res 2018;5(2):348-352
Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)