International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...


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Original Article


Article page

328-333


Authors Details

Roopa Rani Bhandary, Sukanya Shetty, Ashalatha Rao, Srikrishna U


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Markers of atherosclerotic risk in patients with non-alcoholic fatty liver disease: A preliminary study


Original Article

Author Details : Roopa Rani Bhandary, Sukanya Shetty, Ashalatha Rao, Srikrishna U

Volume : 5, Issue : 2, Year : 2018

Article Page : 328-333

https://doi.org/10.18231/2394-6377.2018.0068



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Abstract

Introduction: The prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) is rising continuously. Cardiovascular disease is one among the leading causes of morbidity and premature mortality in patients with NAFLD.
Aims and Objectives: To determine the risk of atherosclerosis in NAFLD subjects diagnosed by USG at K.S.Hegde Charitable hospital.
Materials and Methods:A cross-sectional study involving 203 persons diagnosed with NAFLD were included in the study. Subjects with alcoholic liver disease, renal failure, tuberculosis, hepatitis B and/or C and those on lipid lowering drug were excluded from the study. Lipid profile was measured and Atherogenic Index of Plasma (AIP) was calculated as log (TG/HDL-c). Categorization of the subjects with respect to risk of atherosclerosis was done based on serum LDL-c, non HDL-c and AIP. Statistical analysis was done using Chi Square test and p value < 0>
Results: More than normal values were observed for serum total cholesterol, LDL-c, triglyceride and non HDL-c   in high percentage of NAFLD subjects (76.8%, 84.7%, 70.4% and 72.4% respectively). Serum HDL-c level was low in 53.2% subjects. 51.2% of subjects had high AIP and 23.6% had moderately high AIP.
Conclusion: Results of categorization of the subjects with respect to risk of atherosclerosis based on serum LDL-c, non HDL-c and AIP showed that high percentages of subjects were in moderate and high risk categories. AIP is probably a better marker to determine the risk of atherosclerosis.

Keywords: Atherogenic index of plasma, NAFLD, Non-alcoholic fatty liver disease, Lipids, Cardiovascular.


How to cite : Bhandary R R, Shetty S, Rao A, Srikrishna U, Markers of atherosclerotic risk in patients with non-alcoholic fatty liver disease: A preliminary study. Int J Clin Biochem Res 2018;5(2):328-333

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)