International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

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Original Article


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453- 460


Authors Details

Ayesha Almas, Vanitha Gowda MN


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Serum osteocalcin levels in metabolic syndrome


Original Article

Author Details : Ayesha Almas, Vanitha Gowda MN

Volume : 3, Issue : 4, Year : 2016

Article Page : 453-460


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Abstract

Introduction: Osteocalcin has recently been proposed to play an important role in modulating glucose, lipid and energy metabolism. This study was undertaken to determine serum osteocalcin levels in metabolic syndrome and to study its association with measures of insulin resistance and cardiovascular risk factors.
Methods: The study included 45 cases diagnosed as having metabolic syndrome defined by NCEP ATPIII criteria and 45 normal healthy subjects as controls. A fasting serum sample was collected from each subject and assayed for Fasting Blood Sugar, Lipid Profile, Insulin and Osteocalcin. Body Mass index (BMI), Waist hip ratio (WHR) and Homeostatic model assessment (HOMA) were calculated.
Results: The mean serum Osteocalcin (ng/mL) levels were 4.56±1.75 and 10.302±1.96 in cases and controls respectively (p<0.001). In cases, Hyperglycemia and Hypertriglyceridemia were the most prevalent risk factors. The cases had a statistically significant negative correlation between osteocalcin and BMIand Triglyceride and a statistically significant positive correlation between osteocalcin and High Density Lipoprotein (HDL)(r = +0.964, p< 0.001). Metabolic syndrome subjects had lower serum osteocalcin levels. Greater the number of risk factors present, the lower was the osteocalcin level. The strongest positive association was found between osteocalcin and HDL. Osteocalcin was negatively associated with HOMA, FBS, BMI and triglyceride.
Conclusions: These findings suggest that osteocalcin may have an essential role in modulating glucose and energy metabolism and in the pathophysiology of metabolic syndrome. Further studies may determine the utility of osteocalcin for cardiovascular risk prediction and strategies to increase osteocalcin levels, thus efficiently optimizing glucose, lipid and energy utilization.

Keywords: Osteocalcin; Metabolic syndrome; Body Mass Index; HOMA; Insulin resistance


How to cite : Almas A, Vanitha Gowda Mn, Serum osteocalcin levels in metabolic syndrome. Int J Clin Biochem Res 2016;3(4):453-460

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