International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...


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Original Article


Article page

295-298


Authors Details

Nirensingh Koch, Jaskiran Kaur, Anju Mittal, Akash Gupta, Inder Pal Kaur, Shikha Agarwal


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Status of vitamin D levels in hypothyroid patients and its associations with TSH, T3 and T4 in north Indian population of Meerut, a cross sectional study


Original Article

Author Details : Nirensingh Koch, Jaskiran Kaur, Anju Mittal, Akash Gupta, Inder Pal Kaur, Shikha Agarwal

Volume : 3, Issue : 3, Year : 2016

Article Page : 295-298


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Abstract

Introduction: Vitamin D deficiency has been identified as a risk factor for several autoimmune diseases, cancers, atherosclerosis, etc. Its deficiency has also been shown to be associated with hypothyroidism with inconclusive results. The present study aims to explore the association of vitamin D deficiency with hypothyroidism.
Materials and Methods: This is a cross sectional study conducted in the department of biochemistry Subharti Medical College, Meerut. A total of 152 clinically suspected hypothyroid subjects in the age group of 20-60 years, from both sexes attending Medicine OPD were included in the study.
All the patients were subjected to complete general physical and systemic examination and findings noted. The vitamin D, T3, T4 and TSH were measured in all by enzyme linked fluorescence assay (ELFA) in Vidas PC auto-analyzer from Biomerieux. The patients were then categorized into euthyroid (TSH=0.25-5?IU/ml), subclinical hypothyroid (TSH ?5-7?IU/ml) and overt hypothyroid (TSH?7?IU/ml) based on serum TSH cut off values. The patients were also defined as vitamin D sufficient (?30ng/ml), insufficient (20-30ng/ml) and deficient (<20ng/ml) based upon the recent consensus on vitamin D classification.
Results: The mean value of vitamin D in subclinical hypothyroid (16.73±12.46 ng/ml) and overt hypothyroid (13.23±10.08 ng/ml) were significantly lower than the euthyroid (29.07±19.01 ng/ml) with P value<0.05. Pearson’s correlation analysis between vitamin D and TSH (r=-0.314, P<0.01) have shown a significant negative correlation.
Conclusion: Vitamin D deficiency negatively correlates with TSH. Thus we suggest vitamin D supplementation to all hypothyroid patients.

Keywords: Vitamin D, TSH, Subclinical hypothyroid, Overt hypothyroid, Euthyroid


How to cite : Koch N, Kaur J, Mittal A, Gupta A, Kaur I P, Agarwal S, Status of vitamin D levels in hypothyroid patients and its associations with TSH, T3 and T4 in north Indian population of Meerut, a cross sectional study. Int J Clin Biochem Res 2016;3(3):295-298

Copyright © 2016 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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