International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s more...


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Original Article


Article page

274-277


Authors Details

Neelam Patil, Siddhesh Thorat, Sachin Patharkar*, Alka Nerurkar, Umesh Shinde, Laxman Chougule, Jalinder Sanap, Kalpana Shinde


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Estimation of urinary delta aminolevulinic acid levels in gasoline and petrol pump workers as an index of lead exposure


Original Article

Author Details : Neelam Patil, Siddhesh Thorat, Sachin Patharkar*, Alka Nerurkar, Umesh Shinde, Laxman Chougule, Jalinder Sanap, Kalpana Shinde

Volume : 8, Issue : 4, Year : 2021

Article Page : 274-277

https://doi.org/10.18231/j.ijcbr.2021.058



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Abstract

Lead poisoning is a phenomenon which with growing globalization is being a subject of worry.ALA i.e Amino levulinic acid is a precursor of hemoglobin, which is synthesized in mitochondria by two main components succinyl Co-A and glycine in presence of ALA-S i.e. amino levulinic acid-synthase. Urinary ALA (ALA-U) has been a recommended biomarker for lead exposure. Inhibition of Amino levulinic acid-dehydratase (ALA-D) results into activation of ALA-S which further synthesizes ALA, excess of ALA is accumulated in the blood, plasma, urine. Present manuscript is focused on the estimation of levels of ALA in the urine of gasoline and pertol pump workers, by acidifying the urine to extract out ALA and reading it colorimetrically as they are exposed to fumes released by gasoline, petrol, and petroleum products which contains lead. Awareness and safety measures such as protective masks and gears should be provided by the respective organisations to the workers.
 

Keywords: Estimation of Urinary Delta Aminolevu, ALA- U- Urinary ALA, ALA- D- Amino Levulinic Acid- Dehydratase.


How to cite : Patil N, Thorat S, Patharkar S, Nerurkar A, Shinde U, Chougule L, Sanap J, Shinde K, Estimation of urinary delta aminolevulinic acid levels in gasoline and petrol pump workers as an index of lead exposure. Int J Clin Biochem Res 2021;8(4):274-277

Copyright © 2021 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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