International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...


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Original Article


Article page

219-221


Authors Details

Shalaka S Prabhu, Sachin A Patharkar, Neelam J Patil, Jalinder B Sanap, Kalpana U Shinde, Rupa R Dalvi, Alka V Nerurkar*


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Study of serum malondialdehyde and uric acid levels in patients with malaria


Original Article

Author Details : Shalaka S Prabhu, Sachin A Patharkar, Neelam J Patil, Jalinder B Sanap, Kalpana U Shinde, Rupa R Dalvi, Alka V Nerurkar*

Volume : 8, Issue : 3, Year : 2021

Article Page : 219-221

https://doi.org/10.18231/j.ijcbr.2021.045



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Abstract

Background: Malaria is parasitic disease of humans caused by parasitic protozoan and genus plasmodium, widely present in tropical region. In the blood, the parasite travel to the liver to mature and reproduce. Oxidative stress is generated through the invasion of malarial parasites in human system. Malondialdehyde is a highly reactive compound is assayed in vivo as a biomarker of oxidative stress. Uric acid contributes to the pathology of human malaria by stimulating the production of cytokines from immune system.
Aim: To estimate serum MDA & serum uric acid levels in patients with malarial infection and compare same with healthy individuals.
Settings and Design: This is a cross-sectional observational study, cases and controls were selected using random sampling method, attending hospital OPD.
Materials and Methods: Study includes 50 laboratory diagnosed cases of malaria patients with equal age and sex matched controls. MDA was estimated using MDA - thiobarbituric acid method, uric acid was estimated by phosphotungstic acid method. Standardization of both the methods was carried out prior to experiment.
Results: There is generalized increase in serum MDA and uric acid levels in cases as compared to the control group.
 

Keywords: Malaria, Malonaldehyde (MDA), Uric acid.


How to cite : Prabhu S S, Patharkar S A, Patil N J, Sanap J B, Shinde K U, Dalvi R R, Nerurkar A V, Study of serum malondialdehyde and uric acid levels in patients with malaria. Int J Clin Biochem Res 2021;8(3):219-221

Copyright © 2021 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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