International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377


International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...

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K Vani*, Pragna B Dolia

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Cord serum leptin in infants born to diabetic mothers

Original Article

Author Details : K Vani*, Pragna B Dolia

Volume : 8, Issue : 3, Year : 2021

Article Page : 211-218

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Objective: In genetically diabetes-prone populations, maternal diabetes during pregnancy increases the risk of their children developing diabetes and obesity (the vicious cycle of type 2 diabetes). Fetal hyperinsulinemia at birth acts as a marker of this risk. The objective of this study is to find out whether cord blood leptin concentrations are increased in offspring of mothers with type 2 and gestational diabetes mellitus (GDM) and to evaluate gender differences if any, in their levels.
Materials and Methods: Cord Serum Leptin measured by ELISA: 1. Cord Blood from 40 babies (20M, 20F) born to GDM Mothers. 2: Cord Blood from 20 babies (9M, 11F) born to Type 2 DM Mothers. 3. Cord Blood from 30 babies (15M, 15F) born to Non Diabetic Mothers.
Results: Babies born to mothers with both type 2 diabetes and GDM had higher birth weight. They also had higher Leptin concentrations [ng/ml] compared to Controls; Leptin concentrations in Type 2 Diabetes -Mean [42.32+24.09], in GDM – Mean [40.31+22.71] & in Control subjects – Mean [23.87+15.48]. Birth weight of the female babies were also higher than that of male babies.Leptin concentrations were not significantly higher in the female babies in comparison to the male babies.
Conclusion: High cord leptin, birth weight and ponderal index (kilograms per cm), in babies born to Type 2 diabetes and GDM mothers.

Keywords: Leptin, Ponderal Index, Type2 DM, GDM

How to cite : Vani K, Dolia P B, Cord serum leptin in infants born to diabetic mothers. Int J Clin Biochem Res 2021;8(3):211-218

Copyright © 2021 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

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