International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377


International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...

Article type

Review Article

Article page


Authors Details

VL Asha Latha*

Article Metrics

View Article As


Downlaod Files


Article statistics

Viewed: 69

PDF Downloaded: 26

Progression of knowledge in diabetes mellitus and covid-19

Review Article

Author Details : VL Asha Latha*

Volume : 8, Issue : 3, Year : 2021

Article Page : 163-168

Suggest article by email


The Coronavirus Disease 19 (COVID-19) is a pandemic infectious disease caused by the novel corona virus Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). Diabetes mellitus (DM) and hyperglycemia are among the major comorbidities in patients with COVID-19 which might modulate immune and inflammatory responses leading to poor outcomes. Several reports show that patients with DM and COVID-19 are at an increased risk for developing severe complications including acute respiratory distress syndrome, multi-organ failure, and death. Furthermore, compromised innate immunity, pro-inflammatory cytokine milieu, reduced expression of ACE-2 and use of renin-angiotensin-aldosterone system antagonists in diabetic patients may also contribute to poor prognosis in COVID-19. However, the mechanisms underlying the relationship between COVID-19 and DM remain to be elucidated. The severity and mortality was significantly higher in diabetic patients which may predispose patients with COVID-19 to poor outcomes. Most of these conclusions are preliminary, and further investigation of the optimal management in diabetic patients is necessary. Thus, it is imperative that diabetic patients should take all necessary precautions and ensure good glycemic control amid with COVID-19 pandemic.

Keywords: Angiotensin converting enzyme­ 2, Corona virus disease, Diabetes mellitus, Hyperglycemia, Pathophysiology, SARS­ CoV­ 2 1.

How to cite : Latha V A, Progression of knowledge in diabetes mellitus and covid-19. Int J Clin Biochem Res 2021;8(3):163-168

Copyright © 2021 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Wiki in hindi