International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...


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Original Article


Article page

120-123


Authors Details

C Suvarna Devi, U Sreedhar, T Sharmila Krishna*, R Viswa Kumar, M Prasad Naidu


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Estimation of glycemic control in patients with type 2 diabetes mellites with various forms of tuberculosis with dots


Original Article

Author Details : C Suvarna Devi, U Sreedhar, T Sharmila Krishna*, R Viswa Kumar, M Prasad Naidu

Volume : 8, Issue : 2, Year : 2021

Article Page : 120-123

https://doi.org/10.18231/j.ijcbr.2021.026



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Abstract

Background: Since ancient times people are aware of the association between tuberculosis and diabetes mellitus. Patients with tuberculosis and diabetes experience worse clinical manifestations, increased risk of treatment failure, recurrence, and death. The present study was conducted to evaluate glycosylated hemoglobin (HbA1c) and blood glucose levels, in patients with Type - 2 diabetes mellitus with various forms of tuberculosis who are on RNTCP DOTS and antidiabetic regimens.
Materials and Methods: The study subjects included Type-2 diabetes mellitus with tuberculosis who are registered under RNTCP DOTS, in Dept of Pulmonology, PESIMSR, Kuppam, Chittoor district. Study groups comprises, 20 cases of type 2 DM WITH TB who are on oral hypo glycemic agents (OHA), 20 cases of Type 2DM WITH TB who are on oral hypoglycemic agents (OHA) with insulin, 20 cases of Type 2 DM WITH TB who are on insulin. HbAc is measured by fully automatic Bio-Rad D10 - HbA1c Analyzer. Blood glucose levels are estimated by auto analyser VITROS 250 in PESIMSR, Kuppam.
Results: The mean HbA1c levels showed good control in those patients kept on insulin alone compared to OHA and OHA with insulin groups (P <0> Conclusion: The study revealed that increased levels of Glycosylated haemoglobin (HbA1C) are observed in those patients kept on OHA alone with DOTS as compared with other two groups. There is strong interaction between anti tubercular drugs and OHA which in turn leads to poor glycemic control. Poor glycemic state in diabetic patients is having strong impact on TB treatment outcome.


Keywords: Type- 2 diabetes mellitus (DM), Tuberculosis (TB), Oral hypo glycemic agents (OHA), Insulin, RNTCP, DOTS, Glycosylated hemoglobin (HbA1c), Blood glucose level.


How to cite : Devi C S, Sreedhar U, Krishna T S, Kumar R V, Naidu M P, Estimation of glycemic control in patients with type 2 diabetes mellites with various forms of tuberculosis with dots. Int J Clin Biochem Res 2021;8(2):120-123

Copyright © 2021 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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