International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...


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Original Article


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33-39


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Pavana A*, Vasudha K C, Pramila Kalra


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Urinary transferrin as early marker of renal damage in type II diabetes mellitus: A case–control study


Original Article

Author Details : Pavana A*, Vasudha K C, Pramila Kalra

Volume : 8, Issue : 1, Year : 2021

Article Page : 33-39

https://doi.org/10.18231/j.ijcbr.2021.008



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Abstract

Background: Microalbuminuria is a reversible stage of renal dysfunction and its detection allows early intervention and treatment of diabetic nephropathy. Therefore, a more reliable biomarker is required to diagnose early, reversible stage of renal dysfunction.
Aim: To evaluate the utility of urinary transferrin (UTRANS) as an early predictive marker in type II diabetes mellitus (T2DM).
Settings and Design: This cross-sectional study included 40 normoalbuminuric and 20 microalbuminuric T2DM patients and 20 clinically healthy controls.
Materials and Methods: All baseline characteristics such as glucose (fasting and postprandial), serum creatinine, HbA1c, urinary albumin, creatinine, and UTRANS were estimated.
Statistical Analyses: SPSS software version 20, R studio 3.6.2. Shapiro test, Chi-square test, Analysis of variance, Kruskal Wallis, and receiver operating characteristic (ROC).
Results: Urinary albumin-to-creatinine ratio and UTRANS showed a significant difference among normoalbuminuric and microalbuminuric T2DM patients compared to controls (P = 0.000). UTRANS and TRANS/creatinine ratio positively correlated in normoalbuminuric, macroalbuminuric and control groups (P < 0>0.9), indicating UTRANS was able to differentiate between healthy controls, normoalbuminuric, and microalbuminuric T2DM subjects.
Conclusion: UTRANS may act as a potential biomarker that can be used as an early screening marker for renal injury, even before progression to the stage of microalbuminuria.

Keywords: Type 2 diabetes mellitus, Diabetic nephropathies, Albuminuria, Transferrin, Kidney tubules.


How to cite : Pavana A, Vasudha K C, Kalra P , Urinary transferrin as early marker of renal damage in type II diabetes mellitus: A case–control study. Int J Clin Biochem Res 2021;8(1):33-39

Copyright © 2021 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)