International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...


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Original Article


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25-28


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Pangajam P, Veena Juliette A*


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Association between thyroid hormones & lipid profile in type 2 diabetes mellitus patients- A case control study in tertiary care hospital


Original Article

Author Details : Pangajam P, Veena Juliette A*

Volume : 8, Issue : 1, Year : 2021

Article Page : 25-28

https://doi.org/10.18231/j.ijcbr.2021.006



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Abstract

Background: Diabetes mellitus & thyroid dysfunction are the most common endocrinological disorders in the current era. Diabetes mellitus is a group of metabolic disorders usually associated with dyslipidemia which increases risk of cardiovascular disorders and resultant morbidity & mortality. Thyroid dysfunction particularly hypothyroidism is frequently encountered in diabetic patients. T2DM results in reduction in thyroid releasing hormone (TRH) synthesis & limits T3 & T4 production, which results in increased total cholesterol & LDL in circulation. By studying the association of thyroid hormones & lipid profile in diabetes patients, we can enhance the knowledge about the interrelation between diabetes, thyroid
hormones & dyslipidemia.
Aim: To study the association between thyroid hormones & lipid profile in Type 2 Diabetes Mellitus patients.
Methodology: This is a case control study comprising of 50 cases (T2DM) & 50 age & sex matched healthy controls. Fasting blood sample was taken and analysed for blood sugar, lipid profile, Triiodothyronine(T3), Thyroxine(T4) & TSH.
Results: In this study, higher serum level of total cholesterol, LDL-cholesterol & triglycerides seen in T2DM patients. Also significantly lower T3&T4 and higher TSH are observed in T2DM. Moreover, there was a significant positive correlation between TSH and TC, LDL-C and TGL & significant negative correlation between T3&T4 and TC, LDL-C & TGL.
Conclusion: Thyroid dysfunction is associated with lipid dysregulation in T2DM patients. Early & routine screening of thyroid disorders in T2DM patients can reduce morbidity due to dyslipidemia.

Keywords: Dyslipidemia, T2DM, Thyroid hormones.


How to cite : Pangajam P, Veena Juliette A, Association between thyroid hormones & lipid profile in type 2 diabetes mellitus patients- A case control study in tertiary care hospital. Int J Clin Biochem Res 2021;8(1):25-28

Copyright © 2021 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)