International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the  Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...


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Original Article


Article page

411-415


Authors Details

Syeda Shahana Jalees*, Syed Tamkeen Hussain


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Adenosine deaminase and lactate dehydrogenase levels in serum and cerebrospinal fluid of patients with tuberculous meningitis


Original Article

Author Details : Syeda Shahana Jalees*, Syed Tamkeen Hussain

Volume : 7, Issue : 3, Year : 2020

Article Page : 411-415

https://doi.org/10.18231/j.ijcbr.2020.088



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Abstract

Meningitis is an active inflammatory condition of CNS. However prompt and precise aetiological diagnosis
remains a challenge. Often a thorough CSF examination may not give a precise diagnosis.
There is considerable urgency in establishing correct diagnosis in patients with tuberculous meningitis
because specific therapy is most effective when initiated early in course of illness, delay may cause
irreversible brain damage.
Diagnosis often rests on circumstantial evidence such as history, typical CSF findings and other evidence for
presence of tuberculosis such as acid fast bacilli in sputum, positive tuberculosis test and suspicious Chest
x-ray. Under present study the role of enzymes such as adenosine deaminase and lactate dehydrogenase has
been evaluated in diagnosis of tuberculous meningitis. Result of the study suggest that adenosine deaminase
level in CSF and serum may be a useful parameter along with other routine estimations. The enzyme activity
is high in disease such as tuberculosis where cellular mediated immunity is stimulated.
Estimation of lactate dehydrogenase levels may not be a specific parameter for tuberculous meningitis this
requires further studies in patients of meningitis with different aetiological diagnosis.

Keywords: Tuberculous meningitis, ADA, LDH in Serum and CSF.


How to cite : Jalees S S , Hussain S T , Adenosine deaminase and lactate dehydrogenase levels in serum and cerebrospinal fluid of patients with tuberculous meningitis. Int J Clin Biochem Res 2020;7(3):411-415

Copyright © 2020 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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