International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing more...
Author Details :
Volume : 7, Issue : 1, Year : 2020
Article Page : 138-141
Chronic Kidney disease is a recognized public health problem with a huge social and economical impact
on the individual, family, society and country. Renal failure is a systemic disease and induces a slow
and progressive decline of kidney function aggravated by various factors such as diabetes, infections, auto
immune diseases and toxic chemicals.
Aim: The study was aimed to estimate malondialdehyde, urea and creatinine levels in Chronic renal failure
Materials and Methods: The study was conducted in the department of Biochemistry, Government
medical college, Anantapuramu, Andhra Pradesh. Study subjects were divided in to 2 groups: Group -
1: healthy controls (35) with age group 35-65 years, Group -2 : CRF patients (35) age group 35 -65 years .
Blood Sample was analyzed for plasma glucose, Blood urea, serum creatinine and serum Malondialdehyde.
Results: The mean and standard deviation of Serum Malondialdehyde, blood urea and serum Creatinine
in Chronic renal failure patients (Group-2) was higher compared to controls (Group-1) (p<0> Significant positive correlation was observed between serum Malondialdehyde and serum creatinine.
A positive correlation was observed between serum Malondialdehyde and blood urea (r= 0.40576).
Significant positive correlation existed between Malondialdehyde and serum creatinine (r=0.46832).
Conclusion: In our study on chronic renal failure patients and age matched healthy controls, the renal
parameters – urea, creatinine and BUN were elevated. In addition Malondialdehyde was found to be
significantly elevated showing a pro oxidant status in CRF patients.
Keywords: Chronic Renal Failure CRF, Malondialdehyde MDA, Creatinine.
How to cite : Sreenivasulu U, Prasad B R S, Durga T, Study of serum malondialdehyde levels in chronic renal failure Patients: A hospital based study in Govt. general hospital, Anantapuramu, Andhra Pradesh. Int J Clin Biochem Res 2020;7(1):138-141
Copyright © 2020 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)